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Mezoxia 160mg Tablet (14pcs Pot)
Megestrol Acetate is a synthetic drug with antineoplastic and progestational properties. Although the exact mechanism of its antineoplastic effects on endometrial carcinoma remains unclear, it is believed to involve pituitary gonadotrophin suppression, leading to reduced estrogen secretion.
In treating breast cancer, megestrol acetate works by altering the effects of other steroid hormones and directly affecting tumor cells. Hormone receptors in metastatic cancer may vary across tissues. The drug inhibits estrogen-driven gene transcription and cell function alterations. At pharmacologic doses, it reduces hormone-dependent cancer cells and negates estrogen’s stimulatory effects.
Megestrol Acetate achieves peak plasma levels 2 to 3 hours after a single 160 mg oral dose, with a plasma half-life of 33 to 38 hours. Approximately 66% of the dose is excreted in urine, and about 20% is eliminated via feces.
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✅ Description:
Mezoxia tablets are prescribed for the palliative treatment of advanced breast or endometrial carcinoma, including recurrent, inoperable, or metastatic conditions. This medication should not replace established treatments such as surgery, radiation, or chemotherapy.
Safety Advices
Alcohol
UNSAFE
Alcohol consumption may increase the risk of side effects and worsen the disease. So, avoid alcohol consumption while using Mezoxia Tablet.
Pregnancy
UNSAFE
Mezoxia Tablet is generally not recommended for use during pregnancy and in women planning for pregnancy. Consult your doctor before taking the medicine.
Breastfeeding
UNSAFE
Mezoxia Tablet is not generally recommended for use in breastfeeding women. Consult your doctor before taking the medicine.
Driving
CAUTION
Mezoxia Tablet is unlikely to affect your ability to drive/operate machines. Consult your doctor before taking the Mezoxia Tablet.
Kidney
CONSULT YOUR DOCTOR
Mezoxia Tablets should be used with caution in patients with kidney problems such as chronic kidney disease. Consult your doctor before taking Mezoxia Tablet
Liver
CONSULT YOUR DOCTOR
Mezoxia Tablets should be used with caution in patients with severe liver problems. Consult your doctor before taking MEGAHENZ 40MG TABLET
Similar Products
✔️ Tablets: Mezoxia 160 (Megestrol Acetate)
- Breast cancer: 160 mg/day.
- Endometrial carcinoma: 40-320 mg/day in divided doses.
A minimum of two months of continuous treatment is recommended to assess effectiveness
✔️ Megestrol Acetate Overdose Effects
No severe or unexpected adverse effects have been reported in studies using doses as high as 1600 mg/day.
✔️ Interactions
Inform your doctor if you are taking any medicines including prescription, non-prescription, over-the-counter medicines, vitamins, and/or herbal supplements before taking this medicine.
✔️ Contraindications
- Hypersensitivity to Megestrol Acetate or any formulation component.
- Known or suspected pregnancy.
✔️ Side Effects
- Weight Gain: Commonly associated with increased appetite rather than fluid retention.
- Thromboembolic Events: Cases of thrombophlebitis and pulmonary embolism, sometimes fatal, have been reported.
- Glucocorticoid Effects: This may cause diabetes mellitus (new onset or exacerbation), Cushing’s syndrome, and adrenal insufficiency.
- Other Effects: Nausea, dyspnea, tumor flare, hyperglycemia, glucose intolerance, alopecia, hypertension, carpal tunnel syndrome, mood changes, hot flashes, fatigue, sweating, rash, and lethargy.
✔️ Pregnancy and Lactation
- Pregnancy: Category D. Progestational agents are not recommended during the first four months of pregnancy.
- Lactation: Only trace amounts (approximately 0.1%) are excreted into breast milk. However, due to potential risks to the newborn, breastfeeding should be discontinued during treatment.
✔️ Pediatric Patients:
Safety and efficacy have not been established.
✔️ Geriatric Patients:
Limited data exist to determine whether elderly patients respond differently than younger ones
✔️ Precautions and Warnings
- General: Monitor patients undergoing treatment for recurrent or metastatic cancer. Use cautiously in patients with a history of thromboembolic conditions.
- Diabetics: May exacerbate preexisting diabetes, increasing insulin requirements.
✔️ Storage:
Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children.
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